Thinking of Switching Over to Wegovy from Mounjaro?

With more people accessing new weight-loss treatments, a question we’re hearing more often is: “Should I switch from Mounjaro to Wegovy?”

Both medicines are designed to help with weight loss, but they work in slightly different ways — and switching isn’t as simple as swapping one injection for another. Let’s break it down.

How Mounjaro and Wegovy Work

• • Mounjaro (tirzepatide): A dual-acting treatment. It mimics both GLP-1 and GIP, two hormones that regulate blood sugar, appetite, and satiety.
• • Wegovy (semaglutide): A GLP-1 receptor agonist. It focuses on mimicking just GLP-1, which helps you feel fuller for longer and reduces food cravings.

Both can be effective, but some people respond better to one than the other.

Why Consider Switching?

You might think about moving from Mounjaro to Wegovy if:

• Availability issues – supply of Mounjaro has been limited in some areas.

• Side effects – if Mounjaro is causing nausea, stomach upset, or other side effects you find hard to tolerate.

• Weight loss plateau – if you feel you’ve hit a standstill and want to see if Wegovy works differently for you.

• Doctor’s advice – sometimes your prescriber may feel Wegovy is more appropriate for your health history.

What’s Different About the Switch?

1. Dosage & Titration

o Mounjaro and Wegovy have different starting doses and titration schedules. You won’t continue on the “equivalent” dose — your prescriber will usually restart you on the lowest Wegovy dose and gradually increase it.

2. Side Effects

o Common side effects overlap (nausea, diarrhoea, constipation, stomach discomfort).

o Some people report fewer digestive issues on Wegovy, but everyone’s experience is different.

3. Effectiveness

o Clinical trials suggest Mounjaro can produce slightly more weight loss on average compared to Wegovy.

o That said, Wegovy is still very effective and may suit you better personally.

Things to Keep in Mind

• Don’t stop/start without guidance – Always switch under the care of your GP or weight-management provider.

• Expect an adjustment period – Your body may take a few weeks to adapt, and you may notice a change in appetite control.

• Lifestyle still matters – Diet, exercise, sleep, and stress management are key, whichever medication you’re on.

FAQs

👉 Can I take Wegovy straight after stopping Mounjaro?
 Usually yes — however, guidelines recommend a 1-week wash-out period between stopping Mounjaro and starting Wegovy. Your prescriber will advise the safest timing to avoid any overlap.

👉 Will I lose more or less weight on Wegovy? It varies. Some do better on Mounjaro, others on Wegovy. Both are effective tools — results depend on your body, habits, and consistency.

👉 Is Wegovy easier to get hold of?
 At the moment, Wegovy is more widely available in the UK, but both medicines can face supply issues.

Bottom Line

Switching from Mounjaro to Wegovy can make sense for some people, but it’s not a one-size-fits-all decision. Speak with your pharmacist or GP before making the change, and be patient while your body adjusts.

Both medicines can be powerful tools to help you on your weight-loss journey — what matters most is finding the one that works best for you.